IGF2, insulin like growth factor 2, 3481

N. diseases: 604; N. variants: 19
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.900 Biomarker phenotype GENOMICS_ENGLAND Paternally Inherited IGF2 Mutation and Growth Restriction. 26154720 2015
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.900 Biomarker phenotype GENOMICS_ENGLAND Paternally Inherited IGF2 Mutation and Growth Restriction. 26154720 2015
CUI: C0175693
Disease: Russell-Silver syndrome
Russell-Silver syndrome 		0.700 Biomarker disease GENOMICS_ENGLAND Furthermore, the dysmorphic features of affected family members are consistent with a role of deficient IGF-II levels in the cause of the Silver-Russell syndrome. 26154720 2015
CUI: C0004903
Disease: Beckwith-Wiedemann Syndrome
Beckwith-Wiedemann Syndrome 		0.600 Biomarker disease GENOMICS_ENGLAND
CUI: C0004903
Disease: Beckwith-Wiedemann Syndrome
Beckwith-Wiedemann Syndrome 		0.600 Biomarker disease GENOMICS_ENGLAND Paternally Inherited IGF2 Mutation and Growth Restriction. 26154720 2015
CUI: C0004903
Disease: Beckwith-Wiedemann Syndrome
Beckwith-Wiedemann Syndrome 		0.600 Biomarker disease GENOMICS_ENGLAND We describe a family with overgrowth in three generations and Wilms' tumor in two generations, with paternal inheritance of a cis-duplication at 11p15.5 spanning the BWS IC1 region and including H19, IGFII, INS, and TH. 17325026 2007
CUI: C4225307
Disease: GROWTH RESTRICTION, SEVERE, WITH DISTINCTIVE FACIES
GROWTH RESTRICTION, SEVERE, WITH DISTINCTIVE FACIES 		0.600 Biomarker disease GENOMICS_ENGLAND Paternally Inherited IGF2 Mutation and Growth Restriction. 26154720 2015
CUI: C0796160
Disease: MENTAL RETARDATION, X-LINKED, SNYDER-ROBINSON TYPE
MENTAL RETARDATION, X-LINKED, SNYDER-ROBINSON TYPE 		0.310 Biomarker disease GENOMICS_ENGLAND Paternally Inherited IGF2 Mutation and Growth Restriction. 26154720 2015
CUI: C0473935
Disease: Radiolabeled somatostatin analog study
Radiolabeled somatostatin analog study 		0.300 Biomarker phenotype GENOMICS_ENGLAND Paternally Inherited IGF2 Mutation and Growth Restriction. 26154720 2015
CUI: C1855652
Disease: Fetus Small for Gestational Age
Fetus Small for Gestational Age 		0.300 Biomarker phenotype GENOMICS_ENGLAND Paternally Inherited IGF2 Mutation and Growth Restriction. 26154720 2015
CUI: C1855652
Disease: Fetus Small for Gestational Age
Fetus Small for Gestational Age 		0.300 Biomarker phenotype GENOMICS_ENGLAND Paternally Inherited IGF2 Mutation and Growth Restriction. 26154720 2015
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.900 Biomarker phenotype RGD Decreased IGF-II expression in placenta also may contribute to decreased placental growth and, in turn, to IUGR.(ABSTRACT TRUNCATED AT 250 WORDS) 1408464 1992
CUI: C0206624
Disease: Hepatoblastoma
Hepatoblastoma 		0.700 Biomarker disease RGD Changes in the antioxidant defense and hepatic drug metabolizing enzyme and isoenzyme levels, 8-hydroxydeoxyguanosine formation and expressions of c-raf.1 and insulin-like growth factor II genes during the stages of development of hepatocellular carcinoma in rats. 17554210 2007
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.700 Biomarker disease RGD Unlike insulin-like growth factor II, c-raf.1 expression was located in the late basophilic lesions associated with hepatocellular carcinoma. 17554210 2007
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.570 Biomarker disease RGD Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease. 16627931 2006
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.540 Biomarker group RGD Changes in the antioxidant defense and hepatic drug metabolizing enzyme and isoenzyme levels, 8-hydroxydeoxyguanosine formation and expressions of c-raf.1 and insulin-like growth factor II genes during the stages of development of hepatocellular carcinoma in rats. 17554210 2007
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.540 Biomarker disease RGD This is an extensive study in a defined initiation-promotion hepatocellular carcinoma model of hepatocarcinogenesis (in rats) in which many important marker enzymes and isoenzymes and 8-hydroxydeoxyguanosine formation have been studied together with two very important cellular proliferating genes, insulin-like growth factor II and c-raf.1, known for their role in hepatocellular cancer development. 17554210 2007
CUI: C0019284
Disease: Diaphragmatic Hernia
Diaphragmatic Hernia 		0.500 Therapeutic phenotype RGD Prenatal administration of retinoic acid increases the trophoblastic insulin-like growth factor 2 protein expression in the nitrofen model of congenital diaphragmatic hernia. 24352370 2014
CUI: C0025261
Disease: Memory Disorders
Memory Disorders 		0.500 Therapeutic disease RGD Acetyl-L-carnitine rescues scopolamine-induced memory deficits by restoring insulin-like growth factor II via decreasing p53 oxidation. 24012657 2014
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.400 Biomarker disease RGD Defective IGF2 and IGF1R protein production in embryonic pancreas precedes beta cell mass anomaly in the Goto-Kakizaki rat model of type 2 diabetes. 17476475 2007
CUI: C0011854
Disease: Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Insulin-Dependent 		0.300 Biomarker disease RGD Thymic expression of insulin-related genes in an animal model of autoimmune type 1 diabetes. 11307180 2001
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.270 Biomarker disease RGD Abnormal Igf2 gene in Prague hereditary hypertriglyceridemic rats: its relation to blood pressure and plasma lipids. 18418699 2008
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.230 Biomarker disease RGD Brain insulin-like growth factor-II mRNA content is reduced in insulin-dependent and non-insulin-dependent diabetes mellitus. 8764603 1996
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.230 Biomarker disease RGD Insulin-like growth factor (IGF) gene expression is reduced in neural tissues and liver from rats with non-insulin-dependent diabetes mellitus, and IGF treatment ameliorates diabetic neuropathy. 9336345 1997
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.210 Therapeutic disease RGD These results demonstrate that short-term administration of the IGF-II/IGFBP-2 complex can prevent loss of BMD associated with disuse osteoporosis and stimulate bone formation in adult rats. 12162999 2002